Podophyllin Cream Price in South Africa (2024)

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Podophyllin Cream stands out as a popular solution for treating genital warts, particularly those around the anus, in South Africa. While available over-the-counter, it’s advisable to consult a doctor before use due to potential side effects. This guide provides insights into Podophyllin Cream, its prices, uses, application methods, and side effects in the South African context.

Podophyllin Cream Price in South Africa

Podophyllin Cream is available in three variants: Cream, Paint, and Fluid. Here’s an overview of the prices based on a survey of various vendors across South Africa:

  1. Podophyllin Cream (20 grams) – From R500
  2. Podophyllin Paint Podowart Fluid Skin Warts/Freckle/Spot – From R650
  3. Podowart Podophyllin Resin Fluid for Stubborn Wart Freckles – From R700
  4. UDL Union Podophyllin Warts Cream for Anus and Vagina – From R450
  5. Podowart Podophyllin Fluid Skin Warts/Freckles/Spots/Tags – From R700

What is Podophyllin?

Podophyllin, also known as Podophyllin resin, is derived from the root of Podophyllum peltatum, a plant native to Eastern North America. It consists of several components, with podophyllotoxin being the most potent medically. Historically, Native Americans used Podophyllin resin for various medicinal purposes.

How does Podophyllin Cream work and what are its uses?

Podophyllotoxin, the active ingredient in Podophyllin Cream, acts as an antimitotic agent, inhibiting the division and multiplication of wart cells. This leads to the death of wart cells, allowing healthy cells to regenerate. Podophyllin Cream is primarily used to treat genital warts and has been historically used for various other medical purposes.

How to apply Podophyllin Cream

To ensure optimal results and minimize side effects, follow these steps for applying Podophyllin Cream:

  1. Wash the affected area thoroughly with soap and water.
  2. Dry the area gently with a clean towel.
  3. Use clean cotton wool or applicators provided in the pack to apply the cream carefully to the affected area.
  4. Apply Podophyllin Cream twice daily for three consecutive days, followed by four days without application.
  5. If warts persist, repeat the application regimen for up to five weeks.

Side Effects of Podophyllin Cream

While generally safe when used as directed, Podophyllin Cream may cause some side effects, including:

  • Itching
  • Superficial ulceration
  • Slight pain
  • Redness or tenderness of the skin

In severe cases, it may lead to bleeding, burning sensations, headaches, dizziness, or vomiting. If any adverse reactions occur, discontinue use and consult a healthcare professional.


Podophyllin Cream offers an effective solution for treating genital warts in South Africa. However, it’s crucial to use it cautiously, following the recommended application guidelines and seeking medical advice if needed.


  1. Can I purchase Podophyllin Cream without a prescription in South Africa?

    • Yes, Podophyllin Cream is available over-the-counter, but it’s advisable to consult a doctor before use.
  2. How long does it take for Podophyllin Cream to work?

    • Podophyllin Cream typically requires several weeks of consistent application for optimal results
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